Catalog of Lung Cancer Gene Mutations Among Chinese Patients

Xinying Xue; Idorenyin Asuquo; Lei Hong; Jie Gao; Zhouhuan Dong; Li Pang; Tianjiao Jiang; Mingming Meng; Jingbo Fan; Jiaxin Wen; Hui Deng; Xuelei Zang; Xidong Ma; Rui Guo; Chong Qin; Yao Meng; Heji Ma; Jun Han; Haijiao Wang; Zhiqiang Xue; Dahai Zhao; Dongliang Lin; Lei Pan

doi:10.3389/fonc.2020.01251

Catalog of Lung Cancer Gene Mutations Among Chinese Patients

Front Oncol. 2020 Aug 4:10:1251. doi: 10.3389/fonc.2020.01251. eCollection 2020.

Authors

Xinying Xue¹, Idorenyin Asuquo², Lei Hong³, Jie Gao⁴, Zhouhuan Dong⁴, Li Pang¹, Tianjiao Jiang⁵, Mingming Meng⁶, Jingbo Fan⁷, Jiaxin Wen⁸, Hui Deng¹, Xuelei Zang⁹, Xidong Ma¹⁰, Rui Guo¹, Chong Qin¹, Yao Meng¹¹, Heji Ma², Jun Han¹², Haijiao Wang¹, Zhiqiang Xue⁸, Dahai Zhao⁷, Dongliang Lin¹³, Lei Pan¹

Affiliations

¹ Department of Respiratory and Critical Care, Beijing Shijitan Hospital, Capital Medical University, Beijing, China.
² Department of Radiology, Jinzhou Medical University, Jinzhou, China.
³ Internal Medicine Department, Xuhui Changqiao Community Health Care Centre, Shanghai, China.
⁴ Department of Pathology, Chinese PLA General Hospital, Beijing, China.
⁵ Department of Radiology, Affiliated Hospital of Qingdao University, Qingdao, China.
⁶ Department of Gastroenterology, Beijing Shijitan Hospital, Capital Medical University, Beijing, China.
⁷ Department of Respiratory and Critical Care, Second Affiliated Hospital of Anhui Medical University, Anhui, China.
⁸ Department of Chest Surgery, Chinese PLA General Hospital, Beijing, China.
⁹ Department of Laboratory, Chinese PLA General Hospital, Beijing, China.
¹⁰ Department of Respiratory and Critical Care, Affiliated Hospital of Weifang Medical University, Shandong, China.
¹¹ Department of Chest Surgery, Beijing Shijitan Hospital, Capital Medical University, Beijing, China.
¹² Department of Radiology, Third Affiliated Hospital of Chongqing Medical University, Chongqing, China.
¹³ Department of Pathology, Affiliated Hospital of Qingdao University, Qingdao, China.

Abstract

Background: Detailed catalog of lung cancer-associated gene mutations provides valuable information for lung cancer diagnosis and treatment. In China, there has never been a wide-ranging study cataloging lung cancer-associated gene mutations. This study aims to reveal a comprehensive catalog of lung cancer gene mutations in china, focusing on EGFR, ALK, KRAS, HER2, PIK3CA, MET, BRAF, HRAS, and CTNNB1 as major targets. Additionally, we also aim to correlate smoking history, gender, and age distribution and pathological types with various types of gene mutations. Patients and Methods: A retrospective data acquisition was conducted spanning 6 years (2013-2018) among all patients who underwent lung cancer surgeries not bronchial or percutaneous lung biopsy at three major tertiary hospitals. Finally, we identified 1,729 patients who matched our inclusion criteria. Results: 1081 patients (62.49%) harbored EGFR mutation. ALK (n = 42, 2.43%), KRAS (n = 201, 11.62%), CTNNB1 (n = 28, 1.62%), BRAF (n = 31, 1.79%), PIK3CA (n = 51, 2.95%), MET (n = 14, 0.81%), HER2 (n = 47, 2.72%), HRAS (n = 3, 0.17%), and other genes(n = 232, 13.4%). Females expressed 55.38% vs. males 44.62% mutations. Among subjects with known smoking histories, 32.82% smokers, 67.15% non-smokers were observed. Generally, 51.80% patients were above 60 years vs. 48.20% in younger patients. Pathological types found includes LUADs 71.11%, SQCCs 1.68%, ASC 0.75%, LCC 0.58%, SCC 0.35%, ACC 0.17%, and SC 0.06%, unclear 25.19%. Conclusion: We offer a detailed catalog of the distribution of lung cancer mutations. Showing how gender, smoking history, age, and pathological types are significantly related to the prevalence of lung cancer in China.

Keywords: China; aging; gene mutation; lung cancer; pathology; tobacco smoking.