Non-invasive Assessment of Vaccine-Induced HPV Antibodies via First-Void Urine

Front Immunol. 2020 Aug 5:11:1657. doi: 10.3389/fimmu.2020.01657. eCollection 2020.

Abstract

The potential of first-void (FV) urine as a non-invasive method to monitor human papillomavirus (HPV) vaccination has been reported, mainly focusing on urine as a sample to assess HPV DNA. Besides HPV DNA, vaccine-induced HPV antibodies originating from cervicovaginal secretions were recently shown to be detectable in FV urine as well. This presents a novel opportunity for non-invasive sampling to monitor HPV antibody status in women participating in large epidemiological studies and HPV vaccine trials. The simultaneous assessment of both HPV infection and immunogenicity on a non-invasive, readily obtained sample is particularly attractive.

Keywords: HPV antibodies; HPV serology; HPV vaccination; humaan papillomavirus; urine.

Publication types

  • Research Support, Non-U.S. Gov't

MeSH terms

  • Alphapapillomavirus / immunology*
  • Antibodies, Viral / urine*
  • Biomarkers / urine
  • Female
  • Humans
  • Immunogenicity, Vaccine*
  • Papillomavirus Infections / diagnosis*
  • Papillomavirus Infections / immunology
  • Papillomavirus Infections / urine
  • Papillomavirus Infections / virology
  • Papillomavirus Vaccines / therapeutic use*
  • Predictive Value of Tests
  • Reproducibility of Results
  • Urinalysis

Substances

  • Antibodies, Viral
  • Biomarkers
  • Papillomavirus Vaccines