Biology of Interleukin-17 and Its Pathophysiological Significance in Sepsis

Front Immunol. 2020 Jul 28:11:1558. doi: 10.3389/fimmu.2020.01558. eCollection 2020.

Abstract

The interleukin (IL)-17 family includes six structure-related cytokines (A-F). To date, majority of studies have focused on IL-17A. IL-17A plays a pivotal role in various infectious diseases, inflammatory and autoimmune disorders, and cancer. Several recent studies have indicated that IL-17A is a biomarker as well as a therapeutic target in sepsis. In the current review, we summarize the biological functions of IL-17, including IL-17-mediated responses and signal transduction pathways, with particular emphasis on clinical relevance to sepsis.

Keywords: cytokine; immune response; inflammatory response; interleukin-17; sepsis.

Publication types

  • Research Support, Non-U.S. Gov't
  • Review

MeSH terms

  • Animals
  • Biomarkers
  • Cytokines / metabolism
  • Disease Management
  • Disease Susceptibility*
  • Humans
  • Interleukin-17 / genetics*
  • Interleukin-17 / metabolism*
  • Receptors, Interleukin-17 / metabolism
  • Sepsis / complications
  • Sepsis / diagnosis
  • Sepsis / etiology*
  • Sepsis / metabolism*
  • Signal Transduction
  • T-Lymphocyte Subsets / immunology
  • T-Lymphocyte Subsets / metabolism

Substances

  • Biomarkers
  • Cytokines
  • Interleukin-17
  • Receptors, Interleukin-17