P53 in the impaired lungs

Mohammad A Uddin; Nektarios Barabutis

doi:10.1016/j.dnarep.2020.102952

P53 in the impaired lungs

DNA Repair (Amst). 2020 Nov:95:102952. doi: 10.1016/j.dnarep.2020.102952. Epub 2020 Aug 19.

Authors

Mohammad A Uddin¹, Nektarios Barabutis²

Affiliations

¹ School of Basic Pharmaceutical and Toxicological Sciences, College of Pharmacy, University of Louisiana Monroe, Monroe, Louisiana 71201, USA.
² School of Basic Pharmaceutical and Toxicological Sciences, College of Pharmacy, University of Louisiana Monroe, Monroe, Louisiana 71201, USA. Electronic address: barabutis@ulm.edu.

Abstract

Our laboratory is focused on investigating the supportive role of P53 towards the maintenance of lung homeostasis. Acute lung injury, acute respiratory distress syndrome, chronic obstructive pulmonary disease, pulmonary fibrosis, bronchial asthma, pulmonary arterial hypertension, pneumonia and tuberculosis are respiratory pathologies, associated with dysfunctions of this endothelium defender (P53). Herein we review the evolving role of P53 towards the aforementioned inflammatory disorders, to potentially reveal new therapeutic possibilities in pulmonary disease.

Keywords: Endothelium; Inflammation; Vascular barrier; Vasculature.

Publication types

Research Support, N.I.H., Extramural
Research Support, Non-U.S. Gov't
Review

MeSH terms

Animals
Humans
Lung / metabolism*
Lung / pathology
Lung Diseases / metabolism
Lung Diseases / pathology
Tumor Suppressor Protein p53 / metabolism*

Substances

Tumor Suppressor Protein p53

Grants and funding

P20 GM103424/GM/NIGMS NIH HHS/United States