Structure of DNA polymerase ζ: capturing the getaway driver

Nat Struct Mol Biol. 2020 Oct;27(10):1-2. doi: 10.1038/s41594-020-0502-9.

Abstract

During translesion synthesis, eukaryotic DNA polymerase ζ (zeta) carries out extension from a wide range of DNA lesions. In this issue, Malik et al. (2020) (1) present the cryo-EM structure of polymerase ζ and show how it catalyzes the extension step of translesion synthesis.

MeSH terms

  • Cryoelectron Microscopy
  • DNA Polymerase III / chemistry
  • DNA Polymerase III / metabolism
  • DNA Repair
  • DNA-Directed DNA Polymerase / chemistry
  • DNA-Directed DNA Polymerase / metabolism
  • Models, Molecular
  • Protein Conformation
  • Saccharomyces cerevisiae Proteins / chemistry
  • Saccharomyces cerevisiae Proteins / metabolism

Substances

  • Saccharomyces cerevisiae Proteins
  • DNA polymerase zeta
  • DNA Polymerase III
  • DNA-Directed DNA Polymerase
  • REV3 protein, S cerevisiae