Restricted cubic spline Cox proportional hazard regression model analysis is an important method of epidemiological multivariate survival analysis. By comparing the typical Cox regression model and the restricted cubic spline Cox regression model, this study expounds the limitations of the typical Cox regression model, and explains the basic principles and implementation process of the restricted cubic spline Cox proportional hazard regression model. When the follow-up data does not meet the application conditions of the typical Cox regression model, this method can be used to realize the correlation analysis between continuous exposure and outcomes.
限制性立方样条Cox比例风险回归模型分析是流行病学多因素生存分析的重要方法。本研究通过对典型Cox比例风险回归模型和限制性立方样条Cox比例风险回归模型比较，阐述了典型Cox比例风险回归模型的局限性，以及限制性立方样条Cox比例风险回归模型基本原理与实现过程。在随访数据不满足典型Cox比例风险回归模型应用条件时，可采用该方法实现连续性暴露与结局之间的关联分析。.
Keywords: Cox proportional hazards models; Follow-up studies; Linear models; Models, statistical; Restricted cubic spline.