Objective: To explore the association between maternal bisphenol A (BPA) exposure during pregnancy and neurobehavioral development in infant. Methods: Participants were from the Ma'anshan Birth Cohort, which was established from October 2008 to October 2010 based on four municipal medical and health institutions in Ma'anshan. High-performance liquid chromatography-tandem mass spectrometry was applied for the determination of serum BPA concentration in 1 783 pregnant women sampled at their first filing, and during 2.97 to 28.1 months age of the infants. Neurobehavioral development were assessed by 0-6-year-old pediatric examination table of neuropsychological development. Generalized linear model was used to analyze the association between serum BPA levels during pregnancy and infants' neurobehavioral development. Results: A total of 931 mother-child pairs had complete data on serum BPA detection during pregnancy and assessment of infants' neurobehavioral development status. The age of pregnant women at their first filing was (26.67±3.45) years old, and the M (P25,P75) of serum BPA concentration (ng/ml) was 0.23 (0.11, 0.52), with a detection rate of 84.1% (783/931). The age of infants was (13.18±5.46) months, and 53.5% (498) were boys. The developmental quotient scores of large motor, fine motor, adaptive ability, language ability and social behaviors of infants were (97.88±16.32), (97.16±15.35), (99.64±15.47), (95.3±16.04) and (98.95±14.76) points, respectively. Generalized linear model showed that after adjusting for factors such as delivery mode, feeding mode, family per capita monthly income, preterm delivery, gender, maternal age, residence, pre-pregnancy body mass index and residence time, serum BPA level in pregnancy was negatively associated with infant's development of social behavior [β (95%CI):-2.42 (-4.71, -0.12)]. The post-stratification analysis by infant age revealed that the serum BPA level in pregnancy was only negatively associated with the development of language and social behavior developmental quotient scores in infants between the ages of 12 and 18 months, with β (95%CI) about -6.66 (-13.06, -0.25) and -7.401 (-12.97, -1.83), respectively. Conclusion: BPA exposure during pregnancy affects language and social behavior development in infants, and the detection window is between 12 and 18 months old of the infant.
目的： 探索母亲孕期双酚A（BPA）暴露与婴幼儿神经行为发育的关联。 方法： 对象源自马鞍山市出生队列，该队列于2008年10月至2010年10月以马鞍山市4家市级医疗卫生机构为基础建立。采用固相萃取-同位素内标-高效液相色谱串联质谱检测1 783名孕妇首次建档时采集血清的BPA浓度，于婴幼儿2.97~28.1月龄时，采用《0~6岁小儿神经心理发育检查表（1999年版）》评估其神经行为发育情况，采用广义线性模型分析孕期血清BPA水平与婴幼儿神经行为发育的关联。 结果： 孕期血清BPA检测和婴幼儿神经行为发育状况评估数据完整的母子共931对。首次建档时孕妇年龄为（26.67±3.45）岁，血清BPA浓度（ng/ml）的M（P25，P75）为0.23（0.11，0.52），检出率为84.1%（783/931）。婴幼儿月龄为（13.18±5.46）月龄，男童占53.5%（498名）。婴幼儿大运动、精细动作、适应能力、语言和社交行为发育商得分分别为（97.88±16.32）、（97.16±15.35）、（99.64±15.47）、（95.3±16.04）和（98.95±14.76）分。调整其他相关因素后，孕期血清BPA水平与婴幼儿社交行为发育商得分存在负关联，β（95%CI）值为-2.42 （-4.71，-0.12）。按月龄分层后分析结果显示，孕期血清BPA水平仅与12~18月龄婴幼儿的语言和社交行为发育商得分存在负关联，β（95%CI）值分别为-6.66 (-13.06，-0.25)和-7.40 (-12.97，-1.83)。 结论： 孕期BPA暴露影响婴幼儿的语言和社交行为发育，12~18月龄为其检出窗口期。.
Keywords: Bisphenol A; Child, preschool; Neurobehavioral manifestations; Peripartum period.