Schistosoma antigens as activators of inflammasome pathway: from an unexpected stimulus to an intriguing role

Microbes Infect. 2020 Nov-Dec;22(10):534-539. doi: 10.1016/j.micinf.2020.08.001. Epub 2020 Aug 22.

Abstract

Parasites of the genus Schistosoma are organisms capable of living for decades within the definitive host. They interfere with the immune response by interacting with host's receptors. In this review, we discuss from the first reports to the most recent discoveries regarding the ability of Schistosoma antigens in triggering intracellular receptors and inducing inflammasome activation.

Keywords: Inflammasome; NLRP3; NLRP6; Pyroptosis; SEA; Schistosoma.

Publication types

  • Research Support, Non-U.S. Gov't
  • Review

MeSH terms

  • Animals
  • Antigens, Helminth / metabolism*
  • Dendritic Cells / metabolism
  • Hepatic Stellate Cells / metabolism
  • Inflammasomes / metabolism*
  • Interleukin-1beta / metabolism
  • Macrophages / metabolism
  • NLR Proteins / metabolism
  • Ovum
  • Pyroptosis
  • Schistosoma / immunology
  • Schistosoma / metabolism*
  • Schistosomiasis / metabolism
  • Schistosomiasis / parasitology

Substances

  • Antigens, Helminth
  • Inflammasomes
  • Interleukin-1beta
  • NLR Proteins