Magnetic metal phenolic networks: expanding the application of a promising nanoprobe to phosphoproteomics research

Huimin Chu; Haoyang Zheng; Jizong Yao; Nianrong Sun; Guoquan Yan; Chunhui Deng

doi:10.1039/d0cc04615a

Magnetic metal phenolic networks: expanding the application of a promising nanoprobe to phosphoproteomics research

Chem Commun (Camb). 2020 Sep 24;56(76):11299-11302. doi: 10.1039/d0cc04615a.

Authors

Huimin Chu¹, Haoyang Zheng¹, Jizong Yao¹, Nianrong Sun², Guoquan Yan³, Chunhui Deng⁴

Affiliations

¹ Department of Chemistry, Fudan University, Shanghai, 200433, China. chdeng@fudan.edu.cn.
² Department of Gastroenterology and Hepatology, Zhongshan Hospital, Fudan University, Shanghai, 200433, China. sunnianrong@fudan.edu.cn.
³ Institutes of Biomedical Sciences, Collaborative Innovation Center of Genetics and Development, Fudan University, Shanghai, 200433, China.
⁴ Department of Chemistry, Fudan University, Shanghai, 200433, China. chdeng@fudan.edu.cn and Institutes of Biomedical Sciences, Collaborative Innovation Center of Genetics and Development, Fudan University, Shanghai, 200433, China.

PMID: 32840274
DOI: 10.1039/d0cc04615a

Abstract

A Ti-tannic acid modified magnetic nanoprobe was synthesized via one step, and applied to phosphopeptide extraction. 3456 phosphopeptides and 1285 phosphoproteins were finally identified from 100 μg HeLa cell extracts. This opens up a new avenue for metal phenolic networks in phosphoproteomics research.

MeSH terms

HeLa Cells
Humans
Magnetic Phenomena
Nanoparticles / chemistry*
Organometallic Compounds / chemical synthesis
Organometallic Compounds / chemistry*
Particle Size
Phosphopeptides / analysis*
Phosphoproteins / analysis*
Proteomics*
Surface Properties
Tannins / chemistry*
Titanium / chemistry*

Substances

Organometallic Compounds
Phosphopeptides
Phosphoproteins
Tannins
Titanium