Abstract
Nontoxic adhesive hydrogels are of great importance in tissue engineering. Herein, we report a simple synthesis of a few biocompatible hydrogels from adenine and dopamine immobilized polyacrylic acid (PAA) and alginic acid (Alg) polymers. The adenine-dopamine adduct incorporated hydrogels showed enhanced adhesiveness, transparency and biocompatibility, and induced cell proliferation in 2D and 3D-cell culture models within 24 h. Moreover, blending the modified PAA and Alg polymers (P2P4) further increased the stability and bioactivity of the hydrogel. Such biogels can be developed as smart materials for biomedical applications.
MeSH terms
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Acrylic Resins / chemistry
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Acrylic Resins / pharmacology
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Adenine / chemistry
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Adenine / pharmacology
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Alginic Acid / chemistry
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Alginic Acid / pharmacology
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Biocompatible Materials / chemical synthesis
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Biocompatible Materials / chemistry*
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Biocompatible Materials / pharmacology
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Cell Adhesion / drug effects
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Cell Proliferation / drug effects
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Cell Survival / drug effects
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Dopamine / chemistry
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Dopamine / pharmacology
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Humans
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Hydrogels / chemical synthesis
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Hydrogels / chemistry*
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Hydrogels / pharmacology
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Materials Testing
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Microscopy, Confocal
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Molecular Structure
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Tissue Engineering*
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Tumor Cells, Cultured
Substances
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Acrylic Resins
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Biocompatible Materials
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Hydrogels
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carbopol 940
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Alginic Acid
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Adenine
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Dopamine