GSDME enhances Cisplatin sensitivity to regress non-small cell lung carcinoma by mediating pyroptosis to trigger antitumor immunocyte infiltration

Signal Transduct Target Ther. 2020 Aug 24;5(1):159. doi: 10.1038/s41392-020-00274-9.
No abstract available

Publication types

  • Letter
  • Research Support, Non-U.S. Gov't

MeSH terms

  • Animals
  • Apoptosis / drug effects
  • Carcinoma, Non-Small-Cell Lung / drug therapy*
  • Carcinoma, Non-Small-Cell Lung / genetics
  • Carcinoma, Non-Small-Cell Lung / pathology
  • Cell Line, Tumor
  • Cisplatin / pharmacology*
  • Female
  • Humans
  • Male
  • Mice
  • Middle Aged
  • Pyroptosis / drug effects*
  • Receptors, Estrogen / drug effects*
  • Xenograft Model Antitumor Assays

Substances

  • GSDME protein, human
  • Receptors, Estrogen
  • Cisplatin