Diagnosis and potential treatments for acute hepatopancreatic necrosis disease (AHPND): a review

Harvey M Santos; Ching-Yi Tsai; Kenth Roger A Maquiling; Lemmuel L Tayo; Abdul R Mariatulqabtiah; Chi-Wen Lee; Kuo Pin Chuang

doi:10.1007/s10499-019-00451-w

Diagnosis and potential treatments for acute hepatopancreatic necrosis disease (AHPND): a review

Aquac Int. 2020;28(1):169-185. doi: 10.1007/s10499-019-00451-w. Epub 2019 Aug 10.

Authors

Harvey M Santos¹, Ching-Yi Tsai¹, Kenth Roger A Maquiling², Lemmuel L Tayo², Abdul R Mariatulqabtiah³, Chi-Wen Lee⁴, Kuo Pin Chuang^{1

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Affiliations

¹ International Program in Animal Vaccine Technology, International College, National Pingtung University of Science and Technology, Neipu, 912 Pingtung Taiwan.
² School of Chemical, Biological and Materials Engineering and Sciences, Mapúa University, 1002 Intramuros, Manila Philippines.
³ Faculty of Biotechnology and Biomolecular Sciences, Universiti Putra Malaysia, 43400 Serdang, Selangor Malaysia.
⁴ Department of Post-Baccalaureate Veterinary Medicine, Asia University, Taichung, 41354 Taiwan.
⁵ Graduate Institute of Animal Vaccine Technology, College of Veterinary Medicine, National Pingtung University of Science and Technology, Neipu, 912 Pingtung Taiwan.
⁶ Research Center for Animal Biologics, National Pingtung University of Science and Technology, Neipu, 912 Pingtung Taiwan.

Abstract

Acute hepatopancreatic necrosis disease (AHPND) or formerly known as early mortality syndrome (EMS) is an emerging disease that has caused significant economic losses to the aquaculture industry. The primary causative agent of AHPND is Vibrio parahaemolyticus, a Gram-negative rod-shaped bacterium that has gained plasmids encoding the fatal binary toxins Pir A/Pir B that cause rapid death of the infected shrimp. In this review, the current research studies and information about AHPND in shrimps have been presented. Molecular diagnostic tools and potential treatments regarding AHPND were also included. This review also includes relevant findings which may serve as guidelines that can help for further investigation and studies on AHPND or other shrimp diseases.

Keywords: Acute hepatopancreatic necrosis disease (AHPND); Diagnosis; Pir A; Pir B; Treatment.

Publication types

Review