The Pd-catalyzed directed thiocyanation reaction of arenes and heteroarenes by C-H bond activation was achieved. In the presence of an electrophilic SCN source, this original methodology offered an efficient tool to access a panel of functionalized thiocyanated compounds (21 examples, up to 78 % yield). Post-functionalization reactions further demonstrated the synthetic utility of the approach by converting the SCN-containing molecules into value-added scaffolds.
Keywords: C−H activation; homogeneous catalysis; palladium; synthetic methodology; thiocyanation.
© 2020 The Authors. Published by Wiley-VCH GmbH.