Applications of Mesoporous Silica-Encapsulated Gold Nanorods Loaded Doxorubicin in Chemo-photothermal Therapy

Nghiem Thi Ha Lien; Anh D Phan; Bui Thi Van Khanh; Nguyen Thi Thuy; Nguyen Trong Nghia; Hoang Thi My Nhung; Tran Hong Nhung; Do Quang Hoa; Vu Duong; Nguyen Minh Hue

doi:10.1021/acsomega.0c01939

Applications of Mesoporous Silica-Encapsulated Gold Nanorods Loaded Doxorubicin in Chemo-photothermal Therapy

ACS Omega. 2020 Aug 7;5(32):20231-20237. doi: 10.1021/acsomega.0c01939. eCollection 2020 Aug 18.

Authors

Affiliations

¹ Center for Quantum and Electronics, Institute of Physics, VAST, Dao Tan 10, Hanoi 10000, Vietnam.
² Faculty of Materials Science and Engineering, Phenikaa Institute for Advanced Study, Phenikaa University, Hanoi 12116, Vietnam.
³ Faculty of Information Technology, Artificial Intelligence Laboratory, Phenikaa University, Hanoi 12116, Vietnam.
⁴ College of Science, Vietnam National University (VNU), Hanoi, 334 Nguyen Trai Road, Thanh Xuan, Hanoi 10000, Vietnam.
⁵ Department of Physics, Le Quy Don Technical University, Cau Giay, Hanoi 10000, Vietnam.

Abstract

We investigate the chemo-photothermal effects of gold nanorods (GNRs) coated using mesoporous silica (mSiO₂) loading doxorubicin (DOX). When the mesoporous silica layer is embedded by doxorubicin drugs, a significant change in absorption spectra enables to quantify the drug loading. We carried out photothermal experiments on saline and livers of mice having GNRs@mSiO₂ and GNRs@mSiO₂-DOX. We also injected the gold nanostructures into many tumor-implanted mice and used laser illumination on some of them. By measuring the weight and size of tumors, the distinct efficiency of photothermal therapy and chemotherapy on treatment is determined. We experimentally confirm the accumulation of gold nanostructures in the liver.