Insights into the role of adipose-derived stem cells: Wound healing and clinical regenerative potential

J Cell Physiol. 2021 Apr;236(4):2290-2297. doi: 10.1002/jcp.30019. Epub 2020 Aug 23.

Abstract

The incidence of acute and chronic wound diseases is rising due to various reasons. With complicated pathogenesis, long course, difficult treatment and high disability, wound diseases have become a major burden for patients, their families, and society. Therefore, the focus of research is to identify new ideas and methods for treatment. Fat grafting has gained increased attention because of its effectiveness in wound treatment, and further analysis has uncovered that the stem cells derived from fat may be the main factor affecting wound healing. We summarize the function of adipose stem cells and analyze their possible mechanisms in tissue repair, helping to provide new ideas for the treatment of wound healing.

Keywords: adipose-derived stem cells; fat grafting; regenerative; tissue repair; wound healing.

Publication types

  • Research Support, Non-U.S. Gov't
  • Review

MeSH terms

  • Adipose Tissue / cytology
  • Adipose Tissue / metabolism
  • Adipose Tissue / transplantation*
  • Animals
  • Cell Differentiation
  • Humans
  • Paracrine Communication
  • Phenotype
  • Regenerative Medicine*
  • Stem Cell Transplantation*
  • Stem Cells / metabolism*
  • Treatment Outcome
  • Wound Healing*
  • Wounds and Injuries / metabolism
  • Wounds and Injuries / pathology
  • Wounds and Injuries / surgery*