Acute liver failure and HELLP syndrome: A clinical case and literature review

Clin Res Hepatol Gastroenterol. 2021 Mar;45(2):101498. doi: 10.1016/j.clinre.2020.07.005. Epub 2020 Aug 20.

Abstract

Background: HELLP syndrome is a pregnancy-related liver disease associated with increased maternal and foetal mortality. In rare cases, it can lead to the development of a subcapsular hepatic haematoma as well as its rupture. This rupture is life-threatening if not urgently treated.

Method: We describe a clinical case of HELLP syndrome involving a ruptured subcapsular liver haematoma and contextualise this with a literature overview.

Clinical case: A 39-year-old woman of 40 weeks' gestation presented to her local Emergency Department with symptoms and serology classically associated with HELLP syndrome. However, she clinically deteriorated and developed a ruptured subcapsular haematoma. She underwent an emergency Caesarean section at her initial hospital. Upon clinical stabilisation, she was transferred to our transplant unit for an urgent liver transplant.

Conclusion: LT is a life-saving procedure for patients with acute liver failure secondary to HELLP syndrome. These patients should be immediately referred to a high-volume transplant centre.

Keywords: HELLP syndrome; Haematoma; Liver necrosis; Liver transplantation.

Publication types

  • Case Reports
  • Review

MeSH terms

  • Adult
  • Cesarean Section
  • Female
  • HELLP Syndrome* / diagnosis
  • Hematoma / etiology
  • Humans
  • Liver Diseases*
  • Liver Failure, Acute* / etiology
  • Pregnancy