Chromosome 3p loss in the progression and prognosis of head and neck cancer

Mushfiq Hassan Shaikh; John W Barrett; Mohammed I Khan; Hugh A J Kim; Peter Y F Zeng; Joe S Mymryk; Anthony C Nichols

doi:10.1016/j.oraloncology.2020.104944

Chromosome 3p loss in the progression and prognosis of head and neck cancer

Oral Oncol. 2020 Aug 19:109:104944. doi: 10.1016/j.oraloncology.2020.104944. Online ahead of print.

Authors

Mushfiq Hassan Shaikh¹, John W Barrett¹, Mohammed I Khan¹, Hugh A J Kim², Peter Y F Zeng¹, Joe S Mymryk³, Anthony C Nichols⁴

Affiliations

¹ Department of Otolaryngology-Head and Neck Surgery, Schulich School of Medicine & Dentistry, Western University, London, Ontario, Canada; Department of Oncology, London Health Sciences Centre, London Regional Cancer Program, London, Ontario, Canada.
² Department of Otolaryngology-Head and Neck Surgery, Schulich School of Medicine & Dentistry, Western University, London, Ontario, Canada.
³ Department of Otolaryngology-Head and Neck Surgery, Schulich School of Medicine & Dentistry, Western University, London, Ontario, Canada; Department of Oncology, London Health Sciences Centre, London Regional Cancer Program, London, Ontario, Canada; Department of Microbiology and Immunology, Western University, London, Ontario, Canada.
⁴ Department of Otolaryngology-Head and Neck Surgery, Schulich School of Medicine & Dentistry, Western University, London, Ontario, Canada; Department of Oncology, London Health Sciences Centre, London Regional Cancer Program, London, Ontario, Canada. Electronic address: Anthony.Nichols@lhsc.on.ca.

PMID: 32828022
DOI: 10.1016/j.oraloncology.2020.104944

Abstract

Head and neck squamous cell carcinoma (HNSCC) is characterized by aggressive behavior with a tendency for recurrence and metastasis. Analyses of The Cancer Genome Atlas (TCGA) data and other cohort studies suggest that the loss of the chromosomal 3p arm is a frequent genetic event observed in both human papillomavirus positive and negative HNSCC. Early molecular analyses (i.e. RFLP, CGH) identified three common regions (3p14.2, 3p21.3 and 3p25) that frequently exhibited loss of genetic material on one arm of the 3p chromosome. More recently, next generation sequencing has revealed the loss of larger regions of this arm. Here we review the role of chromosomal 3p arm loss in early initiation and progression of HNSCC, and its relationship with poor patient prognosis.

Keywords: Carcinogenesis; Chromosomal 3p arm loss; Copy number alterations (CNAs); Head and neck squamous cell carcinoma (HNSCC); Prognostic factor.

Publication types

Review