Potential Cardiovascular and Metabolic Beneficial Effects of ω-3 PUFA in Male Obesity Secondary Hypogonadism Syndrome

Nutrients. 2020 Aug 20;12(9):2519. doi: 10.3390/nu12092519.

Abstract

Long-chain ω-3 polyunsaturated fatty acids (PUFAs) are fundamental biocomponents of lipids and cell membranes. They are involved in the maintenance of cellular homeostasis and they are able to exert anti-inflammatory and cardioprotective actions. Thanks to their potential beneficial effects on the cardiovascular system, metabolic axis and body composition, we have examined their action in subjects affected by male obesity secondary hypogonadism (MOSH) syndrome. MOSH syndrome is characterized by the presence of obesity associated with the alteration of sexual and metabolic functions. Therefore, this review article aims to analyze scientific literature regarding the possible benefits of ω-3 PUFA administration in subjects affected by MOSH syndrome. We conclude that there are strong evidences supporting ω-3 PUFA administration and/or supplementation for the treatment and management of MOSH patients.

Keywords: adipose tissue; body weight; male obesity secondary hypogonadism (MOSH) syndrome; testosterone; ω-3 PUFA.

Publication types

  • Review

MeSH terms

  • Adipose Tissue / metabolism
  • Body Mass Index
  • Body Weight
  • Cardiotonic Agents*
  • Dietary Supplements*
  • Fatty Acids, Omega-3 / administration & dosage*
  • Fatty Acids, Omega-3 / pharmacology*
  • Humans
  • Hypogonadism / complications*
  • Hypogonadism / diet therapy*
  • Male
  • Nutritional Physiological Phenomena / physiology*
  • Obesity / diet therapy
  • Obesity / etiology*
  • Obesity / metabolism*
  • Sex Characteristics*
  • Syndrome
  • Testosterone / metabolism
  • Treatment Outcome

Substances

  • Cardiotonic Agents
  • Fatty Acids, Omega-3
  • Testosterone