Abstract
Target of rapamycin (TOR) is a serine/threonine kinase that modulates cell growth and metabolism in response to environmental changes. Transfer RNA (tRNA) is an abundant and ubiquitous small non-coding RNA that is essential in the translation of mRNAs. Beyond its canonical role, it has been revealed that tRNAs have more diverse functions. TOR complex 1 (TORC1), which is one of the two TOR complexes, regulates tRNA synthesis by controlling RNA polymerase III. In addition to tRNA synthesis regulation, recent studies have revealed hidden connections between TORC1 and tRNA, which are both essential players in eukaryotic cellular activities. Here, we review the accumulating findings on the regulatory links between TORC1 and tRNA-particularly those links in the budding yeast Saccharomyces cerevisiae and the fission yeast Schizosaccharomyces pombe.
Keywords:
TORC1; budding yeast; fission yeast; tRNA.
Publication types
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Research Support, Non-U.S. Gov't
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Review
MeSH terms
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Gene Expression Regulation, Fungal
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Mechanistic Target of Rapamycin Complex 1 / genetics
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Mechanistic Target of Rapamycin Complex 1 / metabolism*
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RNA, Transfer / genetics
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RNA, Transfer / metabolism*
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RNA, Untranslated / genetics
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RNA, Untranslated / metabolism*
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Saccharomyces cerevisiae / genetics
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Saccharomyces cerevisiae / growth & development
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Saccharomyces cerevisiae / metabolism*
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Saccharomyces cerevisiae Proteins / genetics
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Saccharomyces cerevisiae Proteins / metabolism*
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Schizosaccharomyces / genetics
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Schizosaccharomyces / growth & development
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Schizosaccharomyces / metabolism*
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Schizosaccharomyces pombe Proteins / genetics
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Schizosaccharomyces pombe Proteins / metabolism*
Substances
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RNA, Untranslated
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Saccharomyces cerevisiae Proteins
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Schizosaccharomyces pombe Proteins
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RNA, Transfer
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Mechanistic Target of Rapamycin Complex 1