Pharmacokinetics of 10B-p-boronophenylalanine (BPA) in the blood and tumors in human patients: A critical review with special reference to tumor-to-blood (T/B) ratios using resected tumor samples

Abstract

We reviewed ¹⁰B concentration kinetics in the blood and tumors in human patients administered with BPA. The ¹⁰B concentration in the blood peaked at the end of intravenous infusion of BPA, followed by a biphasic-decreasing curve with half-lives for the first and second components of the curve being 0.7-3.7 and 7.2-12.0 h, respectively. The mean tumor-to-blood (T/B) ratio obtained from resected tumor samples was 3.40 ± 0.83 for melanoma and the ratio ranged from 1.4 to 4.7 for glioblastoma.

Keywords: (10)B-p-boronophenylalanine (BPA); BNCT; Blood; Pharmacokinetics; T/B ratio; Tumor.