SnapShot: FABP Functions

Cell. 2020 Aug 20;182(4):1066-1066.e1. doi: 10.1016/j.cell.2020.07.027.

Abstract

Fatty acid binding proteins (FABPs) serve as intracellular chaperones for fatty acids and other hydrophobic ligands inside cells. Recent studies have demonstrated new functions of individual members of the FABP family. This Snapshot describes the overall functions of FABPs in health and disease and highlights emerging roles of adipose FABP (A-FABP) and epidermal FABP (E-FABP) in the fields of obesity, chronic inflammation, and cancer development. To view this SnapShot, open or download the PDF.

MeSH terms

  • Adipocytes / cytology
  • Adipocytes / metabolism
  • Fatty Acid-Binding Proteins / metabolism*
  • Humans
  • Macrophages / cytology
  • Macrophages / metabolism
  • Models, Biological*
  • Neoplasms / metabolism
  • Neoplasms / pathology
  • Obesity / metabolism
  • Obesity / pathology
  • Peroxisome Proliferator-Activated Receptors / metabolism
  • Signal Transduction
  • Skin Diseases / metabolism
  • Skin Diseases / pathology
  • Sterol Esterase / metabolism

Substances

  • FABP4 protein, human
  • FABP5 protein, human
  • Fatty Acid-Binding Proteins
  • Peroxisome Proliferator-Activated Receptors
  • Sterol Esterase