TNFAIP8 variants as potential epidemiological and predictive biomarkers in ovarian cancer

Hongyu Gao; Zhiran Zhang; Liangliang Jiang; Lei Zhang; Ling Qin; Tianbo Liu; Shanshan Yang

doi:10.1186/s12935-020-01490-7

TNFAIP8 variants as potential epidemiological and predictive biomarkers in ovarian cancer

Cancer Cell Int. 2020 Aug 17:20:396. doi: 10.1186/s12935-020-01490-7. eCollection 2020.

Authors

Hongyu Gao¹, Zhiran Zhang², Liangliang Jiang², Lei Zhang³, Ling Qin⁴, Tianbo Liu², Shanshan Yang⁵

Affiliations

¹ Department of Gastroenterologic Surgery, Harbin Medical University Cancer Hospital, Harbin Medical University, Harbin, 150081 China.
² Department of Gynecology, Harbin Medical University Cancer Hospital, Harbin Medical University, 150 Haping Road, Harbin, 150081 China.
³ Department of Ultrasound, Harbin Medical University Cancer Hospital, Harbin Medical University, Harbin, 150081 China.
⁴ Department of Pathology, Harbin Medical University Cancer Hospital, Harbin Medical University, Harbin, 150081 China.
⁵ Department of Gynecological Radiotherapy, Harbin Medical University Cancer Hospital, Harbin Medical University, 150 Haping Road, Harbin, 150081 China.

Abstract

Background: This research aimed to investigate the association between tumor necrosis factor-a-induced protein 8 (TNFAIP8) polymorphisms and ovarian cancer (OC) susceptibility.

Methods: A case-control study of 210 patients with OC and 231 healthy controls was conducted to assess the association between TNFAIP8 polymorphisms (rs11064, rs1045241, and rs1045242) and OC risk in Heilongjiang Province of China. The SNaPshot SNP assay was conducted to detect SNP genotype. Logistic regression analysis was applied to illustrate the underlying association.

Results: Our research found that TNFAIP8 rs11064 and rs1045242 were significantly connected with the susceptibility of OC. Additionally, rs1045242 increased the risk of OC, while rs11064 performed a protective role in the risk of OC. Data revealed that rs1045242 strongly related with advanced FIGO stage, larger residual tumor, and the presence of recurrence.

Conclusions: TNFAIP8 genetic variants, which may play difference roles, were significantly associated with OC susceptibility. The underlying molecular mechanism needs be clarified with scientific evidence.

Keywords: Ovarian cancer; Predictive biomarkers; Recurrence; Susceptibility; TNFAIP8 polymorphism; rs1045242; rs11064.