A Voltage-Responsive Synthetic Cl- -Channel Regulated by pH

Shao-Ping Zheng; Ji-Jun Jiang; Arie van der Lee; Mihail Barboiu

doi:10.1002/anie.202008393

A Voltage-Responsive Synthetic Cl^- -Channel Regulated by pH

Angew Chem Int Ed Engl. 2020 Oct 19;59(43):18920-18926. doi: 10.1002/anie.202008393. Epub 2020 Sep 23.

Authors

Shao-Ping Zheng^{1

2}, Ji-Jun Jiang¹, Arie van der Lee², Mihail Barboiu^{1

2}

Affiliations

¹ Lehn Institute of Functional Materials, School of Chemistry, Sun Yat-Sen University, Guangzhou, 510275, China.
² Institut Europeen des Membranes, Adaptive Supramolecular Nanosystems Group, University of Montpellier, ENSCM-CNRS, Place E. Bataillon CC047, 34095, Montpellier, France.

PMID: 32820831
DOI: 10.1002/anie.202008393

Abstract

Transmembrane protein channels are an important inspiration for the design of artificial ion channels. Their dipolar structure helps overcome the high energy barrier to selectively translocate water and ions sharing one pathway, across the cell membrane. Herein, we report that the amino-imidazole (Imu) amphiphiles self-assemble via multiple H-bonding to form stable artificial Cl^- -channels within lipid bilayers. The alignment of water/Cl^- wires influences the conduction of ions, envisioned to diffuse along the hydrophilic pathways; at acidic pH, Cl^- /H⁺ symport conducts along a partly protonated channel, while at basic pH, higher Cl^- /OH^- antiport translocate through a neutral channel configuration, which can be greatly activated by applying strong electric field. This voltage/pH regulated channel system represents an unexplored alternative for ion-pumping along artificial ion-channels, parallel to that of biology.

Keywords: H-bonding; biomimetics; ion channels; self-assembly; water/Cl− wires.

Publication types

Research Support, Non-U.S. Gov't