Two new pyranoxanthones from the stem bark of Calophyllum pseudomolle P.F. Stevens

Mulyadi Tanjung; Tjitjik Srie Tjahjandarie; Ratih Dewi Saputri; Muhammad Fajar Aldin; Hery Purnobasuki

doi:10.1080/14786419.2020.1808638

Two new pyranoxanthones from the stem bark of Calophyllum pseudomolle P.F. Stevens

Nat Prod Res. 2022 Feb;36(3):822-827. doi: 10.1080/14786419.2020.1808638. Epub 2020 Aug 21.

Authors

Mulyadi Tanjung¹, Tjitjik Srie Tjahjandarie¹, Ratih Dewi Saputri¹, Muhammad Fajar Aldin¹, Hery Purnobasuki²

Affiliations

¹ Natural Products Chemistry Research Group, Organic Chemistry Division, Faculty of Science and Technology, Department of Chemistry, Universitas Airlangga, Surabaya, Indonesia.
² Faculty of Science and Technology, Department of Biology, Universitas Airlangga, Surabaya, Indonesia.

PMID: 32820644
DOI: 10.1080/14786419.2020.1808638

Abstract

Two new pyranoxanthones, calotetrapterins D (1) and E (2), were isolated from the stem bark of Calophyllum pseudomolle P.F. Stevens along with α-mangostin (3). The structures of compounds 1-2 were determined based on 1D NMR (¹H, ¹³C) and 2D NMR (HMQC, HMBC), as well as HRESIMS spectroscopic analysis. Compounds 1-2 showed moderate activity against HeLa and murine leukaemia P-388 cells.

Keywords: Calophyllum pseudomolle; Calotetrapterins D and E; cytotoxicity; pyranoxanthones.

MeSH terms

Animals
Calophyllum*
HeLa Cells
Humans
Magnetic Resonance Spectroscopy
Mice
Molecular Structure
Plant Bark