99mTc-gallic-gold nanoparticles as a new imaging platform for tumor targeting

Tamer M Sakr; M A El-Hashash; A A El-Mohty; Basma M Essa

doi:10.1016/j.apradiso.2020.109269

^99mTc-gallic-gold nanoparticles as a new imaging platform for tumor targeting

Appl Radiat Isot. 2020 Oct:164:109269. doi: 10.1016/j.apradiso.2020.109269. Epub 2020 Jun 15.

Authors

Tamer M Sakr¹, M A El-Hashash², A A El-Mohty³, Basma M Essa⁴

Affiliations

¹ Radioactive Isotopes and Generator Department, Hot Labs Center, Egyptian Atomic Energy Authority (EAEA), P.O. Box 13759, Cairo, Egypt; Radioisotopes Production Facility, Second Egyptian Research Reactor Complex, Egyptian Atomic Energy Authority, 13759, Cairo, Egypt. Electronic address: Tamer_sakr78@yahoo.com.
² Chemistry Department, Faculty of Science, Ain Shams University, Cairo, Egypt.
³ Radioactive Isotopes and Generator Department, Hot Labs Center, Egyptian Atomic Energy Authority (EAEA), P.O. Box 13759, Cairo, Egypt.
⁴ Radioactive Isotopes and Generator Department, Hot Labs Center, Egyptian Atomic Energy Authority (EAEA), P.O. Box 13759, Cairo, Egypt. Electronic address: Basmamohamed24@yahoo.com.

PMID: 32819507
DOI: 10.1016/j.apradiso.2020.109269

Abstract

Early and accurate detection of tumor assists in identifying more effective therapies. Gold nanoparticles (GNPs) were synthesized by green synthesis method using gallic acid (GA) then characterized and labeled with technetium-99m. This new platform was biologically evaluated in both normal and solid tumor bearing mice. The in-vivo study of [^99mTc]Tc-gallic-GNPs via both I.V. and I.T injecton showed a high accumulation in tumor site. As a result, [^99mTc]Tc-gallic-GNPs can be afforded as a potential nano-platform for tumor imaging.

Keywords: Gallic acid; Gold nanoparticles; Imaging platform; Technetium-99m; Tumor.

MeSH terms

Animals
Cell Line, Tumor
Gallic Acid / chemistry*
Gold / metabolism*
Humans
Metal Nanoparticles / chemistry*
Mice
Neoplasms / diagnostic imaging*
Neoplasms / metabolism
Organotechnetium Compounds / metabolism*
Organotechnetium Compounds / pharmacokinetics
Radiopharmaceuticals / metabolism*
Tissue Distribution

Substances

Organotechnetium Compounds
Radiopharmaceuticals
Gallic Acid
Gold