We sequenced 29 carbapenemase-producing Klebsiella pneumoniae isolates from a neonatal intensive care unit in Ghana. Twenty-eight isolates were sequence type 17 with blaOXA-181 and differed by 0-32 single-nucleotide polymorphisms. Improved surveillance and infection control are needed to characterize and curb the spread of multidrug-resistant organisms in sub-Saharan Africa.
Keywords: Ghana; Klebsiella pneumoniae; antimicrobial resistance; bacteria; bloodstream infection; carbapenem; carbapenemase; carbapenemase-producing; neonatal intensive care unit; whole-genome sequencing.