Abstract
A supramolecular photosensitizer was constructed using a tetra-adamantane-functionalized porphyrin and a dimer of permethyl-β-cyclodextrin through host-guest interaction and self-assembly. The porphyrin/cyclodextrin alternating structure of supramolecular photosensitizers not only enhances the water solubility of the photosensitizers, but also effectively inhibits the aggregation-induced quenching of porphyrin photosensitizers.
MeSH terms
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Adamantane / chemistry
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Adamantane / pharmacology*
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Animals
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Antineoplastic Agents / chemical synthesis
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Antineoplastic Agents / chemistry
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Antineoplastic Agents / pharmacology*
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Cell Line, Tumor
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Cell Proliferation / drug effects
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Cell Survival / drug effects
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Cyclodextrins / chemistry
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Cyclodextrins / pharmacology*
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Macromolecular Substances / chemical synthesis
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Macromolecular Substances / chemistry
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Macromolecular Substances / pharmacology
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Mammary Neoplasms, Experimental / drug therapy
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Mammary Neoplasms, Experimental / pathology
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Mice
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Optical Imaging
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Photochemotherapy*
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Photosensitizing Agents / chemical synthesis
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Photosensitizing Agents / chemistry
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Photosensitizing Agents / pharmacology*
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Porphyrins / chemistry
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Porphyrins / pharmacology*
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Solubility
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Water / chemistry
Substances
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Antineoplastic Agents
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Cyclodextrins
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Macromolecular Substances
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Photosensitizing Agents
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Porphyrins
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Water
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Adamantane