Interferon-λ at the Center of the Storm

Matthew R Hendricks; Ram Savan

doi:10.1016/j.immuni.2020.07.024

Interferon-λ at the Center of the Storm

Immunity. 2020 Aug 18;53(2):245-247. doi: 10.1016/j.immuni.2020.07.024.

Authors

Matthew R Hendricks¹, Ram Savan²

Affiliations

¹ Department of Immunology, University of Washington, Seattle, WA 98109, USA.
² Department of Immunology, University of Washington, Seattle, WA 98109, USA. Electronic address: savanram@uw.edu.

Abstract

Type I and III interferons (IFNs) drive effective antiviral functions but differentially affect tissue homeostasis. Using mouse models of severe inflammation, Broggi et al. and Major et al. report in Science that type III IFNs disrupt epithelial cell proliferation and differentiation in the lung.

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MeSH terms

Animals
Antiviral Agents*
Interferon Lambda
Interferons*
Lung
Mice

Substances

Antiviral Agents
Interferons
Interferon Lambda