Recent progress on the role of miR-140 in cartilage matrix remodelling and its implications for osteoarthritis treatment

Li Duan; Yujie Liang; Xiao Xu; Yin Xiao; Daping Wang

doi:10.1186/s13075-020-02290-0

Recent progress on the role of miR-140 in cartilage matrix remodelling and its implications for osteoarthritis treatment

Arthritis Res Ther. 2020 Aug 18;22(1):194. doi: 10.1186/s13075-020-02290-0.

Authors

Li Duan¹, Yujie Liang^{1

2}, Xiao Xu¹, Yin Xiao³, Daping Wang^{4

5}

Affiliations

¹ Department of Orthopedics, Shenzhen Intelligent Orthopaedics and Biomedical Innovation Platform, Guangdong Artificial Intelligence Biomedical Innovation Platform, Shenzhen Second People's Hospital, The First Affiliated Hospital of Shenzhen University Health Science Center, Shenzhen, 518035, China.
² Department of Child and Adolescent Psychiatry, Shenzhen Kangning Hospital, Shenzhen Mental Health Center, Shenzhen, 518003, China.
³ Institute of Health and Biomedical Innovation, Faculty of Science and Engineering, Queensland University of Technology, Kelvin Grove Campus, Brisbane, QLD, 4059, Australia.
⁴ Department of Orthopedics, Shenzhen Intelligent Orthopaedics and Biomedical Innovation Platform, Guangdong Artificial Intelligence Biomedical Innovation Platform, Shenzhen Second People's Hospital, The First Affiliated Hospital of Shenzhen University Health Science Center, Shenzhen, 518035, China. wangdp@mail.sustech.edu.cn.
⁵ Department of Biomedical Engineering, Southern University of Science and Technology, Shenzhen, 518055, China. wangdp@mail.sustech.edu.cn.

Abstract

Cartilage matrix remodelling homeostasis is a crucial factor in maintaining cartilage integrity. Loss of cartilage integrity is a typical characteristic of osteoarthritis (OA). Strategies aimed at maintaining cartilage integrity have attracted considerable attention in the OA research field. Recently, a series of studies have suggested dual functions of microRNA-140 (miR-140) in cartilage matrix remodelling. Here, we discuss the significance of miR-140 in promoting cartilage formation and inhibiting degeneration. Additionally, we focused on the role of miR-140 in the chondrogenesis of mesenchymal stem cells (MSCs). Of note, we carefully reviewed recent advances in MSC exosomes for miRNA delivery in OA treatment.

Keywords: Anabolism; Cartilage matrix; Catabolism; Osteoarthritis; miR-140.

Publication types

Research Support, Non-U.S. Gov't
Review

MeSH terms

Cartilage, Articular*
Chondrocytes
Chondrogenesis / genetics
Humans
MicroRNAs* / genetics
Osteoarthritis* / genetics
Osteoarthritis* / therapy

Substances

MicroRNAs
Mirn140 microRNA, human