With the deeper understanding of the pathophysiology and pathogenesis of non-small cell lung cancer (NSCLC) which threatens human health, NSCLC treatment has entered a new era. Transition from traditional treatment based on surgery, radiotherapy and chemotherapy to individualized and precise targeted therapy and safer and more effective immunotherapy. Immune checkpoint inhibitor therapy has been approved as a first-line or second-line treatment for advanced NSCLC, and has achieved extraordinary clinical results. Meanwhile, other types of immunotherapy are rarely explored in NSCLC. Chimeric antigen receptor modified T cells (CAR-T cells) perform well in treating several hematological malignancies. However, it is not ideal for treating patients with solid tumors including NSCLC. This review aims to systematically explain the latest progress of CAR-T in the treatment of NSCLC, mainly including: CAR molecular target selection, CAR-T function enhancement and related toxicity management, as well as the difficulties and prospects of CAR-T treatment of NSCLC. It aims to open up new perspectives and unique ideas for the immunotherapy of NSCLC, and contribute to the building of tumor immunotherapy. .
【中文题目：CAR-T免疫疗法与非小细胞肺癌：瓶颈与曙光】 【中文摘要：伴随人们对威胁人类健康的非小细胞肺癌（non-small cell lung cancer, NSCLC）更深入的病理生理和发病机制的全新理解，NSCLC治疗已进入一个新时代。从传统以手术、放化疗为基础的治疗过渡到以个体化精准化的靶向治疗和安全性及效能更高的免疫治疗。免疫检查点抑制剂疗法已经被批准为晚期NSCLC一线或者二线的治疗方案，并且取得非同凡响的临床效果。然而，其他类型的免疫治疗在NSCLC中鲜有探索。嵌合抗原受体修饰T细胞（chimeric antigen receptor modified T cells, CAR-T cells）在治疗几种血液系统恶性肿瘤方面表现不俗。然而，其在治疗包括NSCLC在内的实体瘤患者方面却不甚理想。本综述旨在系统阐释CAR-T在NSCLC治疗中的最新进展，主要包括：CAR分子靶标选择、CAR-T功能增强及相关毒性的管理以及CAR-T治疗NSCLC的困境及展望，旨在为NSCLC的免疫治疗开拓新的视角和独特的思路，为肿瘤免疫治疗大厦添砖加瓦。 】 【中文关键词：肺肿瘤；嵌合抗原受体修饰T细胞；靶标；毒性】.
Keywords: Chimeric antigen receptor modified T cells; Lung neoplasms; Target; Toxicity.