Function and regulation of lipid signaling in lymphomagenesis: A novel target in cancer research and therapy

Abstract

To survive under the challenging conditions, cancer cells adapt their own metabolic mechanism(s) to be able steady supplying energy and metabolites for synthesis of new biomass. Aberrant lipid metabolism in cancer cells becomes a hall marker of carcinogenesis. Epidemiologic evidence indicates that fat intake, in particular saturated or animal fat, may increase the risk of lymphoma. Understanding the specific alterations of lymphoma metabolism becomes essential to address malignant transformation, progression, and therapeutic approaches. This review is focused on the lipid metabolism, with emphasis on fatty acid synthase, lipid rafts, exosomes, and metabolic diseases, in distinct lymphoma entities.

Keywords: Exosomes; Fatty acid synthase; Lipid metabolism; Lipid rafts; Lymphoma; Metabolic diseases.