Phenoxybenzamine

Excerpt

Phenoxybenzamine is a medication used in the management and treatment of paroxysmal hypertension and sweating resulting from pheochromocytoma. It is in the nonselective, irreversible antagonist of the alpha-adrenergic receptors class of drugs. This activity reviews the indications, action, and contraindications for phenoxybenzamine as a valuable agent in the treatment of paroxysmal hypertension and sweating resulting from pheochromocytoma and benign prostate hyperplasia. This activity will highlight the mechanism of action, adverse event profile, and other key factors (e.g., off-label uses, dosing, pharmacodynamics, pharmacokinetics, monitoring, relevant interactions) pertinent for members of the interprofessional team in the management of patients with pheochromocytoma and related conditions.