Combined Antiplatelet/Anticoagulant Drug for Cardiac Ischemia/Reperfusion Injury

Laura A Bienvenu; Ana Maluenda; James D McFadyen; Amy K Searle; Eefang Yu; Carolyn Haller; Elliot L Chaikof; Karlheinz Peter; Xiaowei Wang

doi:10.1161/CIRCRESAHA.120.317450

Combined Antiplatelet/Anticoagulant Drug for Cardiac Ischemia/Reperfusion Injury

Circ Res. 2020 Oct 9;127(9):1211-1213. doi: 10.1161/CIRCRESAHA.120.317450. Epub 2020 Aug 17.

Authors

Laura A Bienvenu^{1

2

3}, Ana Maluenda^{1

2}, James D McFadyen^{1

3

4}, Amy K Searle^{1

2

3}, Eefang Yu^{1

2

4}, Carolyn Haller^{5

6}, Elliot L Chaikof^{5

6}, Karlheinz Peter^{1

3

4}, Xiaowei Wang^{2

3

4}

Affiliations

¹ Atherothrombosis and Vascular Biology Laboratory (L.A.B., A.M., J.D.M., A.K.S., E.Y., K.P.).
² Molecular Imaging and Theranostics Laboratory, Baker Heart and Diabetes Institute, Melbourne, VIC, Australia (L.A.B., A.M., A.K.S., E.Y., X.W.).
³ Cardiometabolic Health, University of Melbourne, VIC, Australia (L.A.B., J.D.M., K.P., X.W.).
⁴ Medicine, Monash University, Melbourne, VIC, Australia (J.D.M., A.K.S., E.Y., K.P., X.W.).
⁵ Surgery, Beth Israel Deaconess Medical Center, Harvard Medical School, Boston, MA (C.H., E.L.C.).
⁶ Wyss Institute of Biologically Inspired Engineering of Harvard University, Boston, MA (C.H., E.L.C.).

PMID: 32806996
DOI: 10.1161/CIRCRESAHA.120.317450

No abstract available

Keywords: mice; myocardial infarction; reperfusion; thrombosis; tick anticoagulant peptide.

Publication types

Letter
Research Support, Non-U.S. Gov't

MeSH terms

Animals
Anticoagulants / therapeutic use
Arthropod Proteins / genetics
Arthropod Proteins / therapeutic use*
Humans
Integrin beta3 / metabolism
Intercellular Signaling Peptides and Proteins / genetics
Intercellular Signaling Peptides and Proteins / therapeutic use*
Male
Mice, Inbred C57BL
Myocardial Reperfusion Injury / prevention & control*
Platelet Activation
Platelet Adhesiveness*
Platelet Aggregation Inhibitors / therapeutic use
Platelet Aggregation*
Platelet Membrane Glycoprotein IIb / metabolism
Random Allocation
Recombinant Fusion Proteins / therapeutic use*
Single-Chain Antibodies / genetics
Single-Chain Antibodies / metabolism
Single-Chain Antibodies / therapeutic use*
Thrombosis / etiology

Substances

Anticoagulants
Arthropod Proteins
Integrin beta3
Intercellular Signaling Peptides and Proteins
Platelet Aggregation Inhibitors
Platelet Membrane Glycoprotein IIb
Recombinant Fusion Proteins
Single-Chain Antibodies
tick anticoagulant peptide