T Cell Costimulation Blockade Blunts Age-Related Heart Failure

Circ Res. 2020 Sep 25;127(8):1115-1117. doi: 10.1161/CIRCRESAHA.119.316530. Epub 2020 Aug 17.

Elisa Martini¹, Marco Cremonesi^#^{1

2}, Cristina Panico^#^{3

2}, Pierluigi Carullo^{3

4}, Cecilia Assunta Bonfiglio^{1

2}, Simone Serio³, Elena Jachetti⁵, Mario Paolo Colombo⁵, Gianluigi Condorelli^{3

2

4}, Marinos Kallikourdis^{1

2}

¹ Adaptive Immunity Laboratory (E.M., M.C., C.A.B., M.K.), Humanitas Clinical and Research Center IRCCS, Rozzano, Milan, Italy.
² Humanitas University, Pieve Emanuele, Milan, Italy (M.C., C.P., C.A.B., G.C., M.K.).
³ Department of Cardiovascular Medicine (C.P., P.C., S.S., G.C.), Humanitas Clinical and Research Center IRCCS, Rozzano, Milan, Italy.
⁴ Institute of Genetic and Biomedical Research, Milan Unit, National Research Council, Milan, Italy (P.C., G.C.).
⁵ Molecular Immunology Unit, Department of Research, Fondazione IRCCS Istituto Nazionale dei Tumori, Milan, Italy (E.J., M.P.C.).

^# Contributed equally.

Abstract

Supplemental Digital Content is available in the text.

Keywords: abatacept; aging; heart failure; inflammation; mice.