Two-dimensional MXene/cobalt nanowire heterojunction for controlled drug delivery and chemo-photothermal therapy

Yunxiu Liu; Qiuyang Han; Weizhong Yang; Xueqi Gan; Yuanyi Yang; Kenan Xie; Lu Xie; Yi Deng

doi:10.1016/j.msec.2020.111212

Two-dimensional MXene/cobalt nanowire heterojunction for controlled drug delivery and chemo-photothermal therapy

Mater Sci Eng C Mater Biol Appl. 2020 Nov:116:111212. doi: 10.1016/j.msec.2020.111212. Epub 2020 Jun 20.

Authors

Yunxiu Liu¹, Qiuyang Han¹, Weizhong Yang², Xueqi Gan³, Yuanyi Yang⁴, Kenan Xie¹, Lu Xie⁵, Yi Deng⁶

Affiliations

¹ School of Chemical Engineering, Sichuan University, Chengdu 610065, China.
² College of Materials Science and Engineering, Sichuan University, Chengdu 610065, China.
³ State Key Laboratory of Oral Diseases, West China College of Stomatology, Sichuan University, Chengdu 610041, China.
⁴ School of Civil Engineering and Architecture, Southwest Petroleum University, Chengdu 610500, China.
⁵ State Key Laboratory of Oral Diseases, West China College of Stomatology, Sichuan University, Chengdu 610041, China. Electronic address: xielu2017@163.com.
⁶ School of Chemical Engineering, Sichuan University, Chengdu 610065, China; Department of Mechanical Engineering, The University of Hong Kong, Hong Kong, China. Electronic address: dengyibandeng@scu.edu.cn.

PMID: 32806324
DOI: 10.1016/j.msec.2020.111212

Abstract

Two-dimensional (2D) MXene nanomaterials have explored as a great potential candidate for tumor therapy during recent decades, especially for photothermal therapeutic applications. However, MXene-based drug-carriers cannot be elaborately controlled in cancer therapy. To solve the problem, a heterostructured titanium carbide-cobalt nanowires (Ti₃C₂-CoNWs) nanocarrier is developed for synergetic anticancer with magnetic controlling ability, dual stimuli-responsive drug release, and chemo-photothermal therapy. The structure, drug loading/release behavior, magnetic controlling capacity, photothermal performance, and synergistic therapeutic efficiency of the Ti₃C₂-CoNWs nanocarrier heterojunction are investigated. The heterostructured Ti₃C₂-CoNWs nanocarrier exhibits excellent photothermal conversion efficiency under 808 nm laser irradiation and high drug loading ability (225.05%). The doxorubicin (DOX) release behavior can be triggered by acid pH value (4-6) or near-infrared (NIR) irradiation. The Ti₃C₂-CoNWs nanocarrier heterojunction with synergistic chemo-photothermal therapeutic effect exhibits strong lethality for cancer cells than that of chemotherapy or photothermal therapy (PTT) alone. Therefore, Ti₃C₂-CoNWs nanocarrier heterojunction will be a promising choice for improving the efficiency of cancer treatment.

Keywords: Cobalt nanowires; Doxorubicin; Photothermal-chemo therapy; Titanium carbide.

MeSH terms

Cell Line, Tumor
Cobalt
Doxorubicin / pharmacology
Drug Delivery Systems
Drug Liberation
Hyperthermia, Induced*
Nanoparticles*
Nanowires*
Phototherapy
Photothermal Therapy

Substances

Cobalt
Doxorubicin