Synthesis of Dy-Y co-substituted manganese‑zinc spinel nanoferrites induced anti-bacterial and anti-cancer activities: Comparison between sonochemical and sol-gel auto-combustion methods

M A Almessiere; Y Slimani; S Rehman; Firdos A Khan; E Gökçe Polat; A Sadaqat; Sagar E Shirsath; A Baykal

doi:10.1016/j.msec.2020.111186

Synthesis of Dy-Y co-substituted manganese‑zinc spinel nanoferrites induced anti-bacterial and anti-cancer activities: Comparison between sonochemical and sol-gel auto-combustion methods

Mater Sci Eng C Mater Biol Appl. 2020 Nov:116:111186. doi: 10.1016/j.msec.2020.111186. Epub 2020 Jun 17.

Authors

M A Almessiere¹, Y Slimani¹, S Rehman², Firdos A Khan³, E Gökçe Polat⁴, A Sadaqat⁵, Sagar E Shirsath⁶, A Baykal⁷

Affiliations

¹ Department of Biophysics, Institute for Research and Medical Consultations (IRMC), Imam Abdulrahman Bin Faisal University, P.O. Box 1982, 31441 Dammam, Saudi Arabia.
² Department of Epidemic Disease Research, Institute for Research and Medical Consultations (IRMC), Imam Abdulrahman Bin Faisal University, P.O. Box 1982, 31441 Dammam, Saudi Arabia.
³ Department of Stem Cell Research, Institute for Research and Medical Consultations (IRMC), Imam Abdulrahman Bin Faisal University, P.O. Box 1982, 31441 Dammam, Saudi Arabia. Electronic address: fakhan@iau.edu.sa.
⁴ Department of Engineering Physics, İstanbul Medeniyet University, 34700, Üsküdar, İstanbul, Turkey.
⁵ Mechanical Energy Engineering Depatment, College of Engineering, Imam Abdulrahman Bin Faisal University, P.O. Box 1982, 31441 Dammam, Saudi Arabia.
⁶ School of Materials Science and Engineering, University of New South Wales, Kensington, Sydney, NSW 2052, Australia.
⁷ Department of Nanomedicine Research, Institute for Research and Medical Consultations (IRMC), Imam Abdulrahman Bin Faisal University, P.O. Box 1982, 31441 Dammam, Saudi Arabia.

PMID: 32806294
DOI: 10.1016/j.msec.2020.111186

Abstract

This study described the beneficial properties of ultrasonic irradiation approach to synthesize the spinel-type Dy-Y co-substituted Mn-Zn nanospinel ferrites (NSFs). We have used two different approaches like citrate sol-gel combustion and ultrasonic irradiation routes to produced series of Mn_0.5Zn_0.5Fe_2-2x(Dy_xY_x)O₄ (0.0 ≤ x ≤ 0.05) NSFs (DyY-MnZn NSFs). The structure and morphology of NSFs X-was examined by using XRD, EDX, SEM and TEM methods. We have found that spinel ferrites and hematite phase in DyY-MnZn NSFs produced by citrate sol-gel, while DyY-MnZn NSFs created by ultrasonic irradiation contain a pure phase of spinel ferrite. TEM analysis revealed the spherical nanoparticles with fairly uniform size. We have also analyzed the biological applications of DyY-MnZn NSFs prepared by both methods (ultrasonication and sol-gel) by examining their anti-cancer and anti-bacterial (Escherichia coli and Staphylococcus aureu) activities. We have found that both methods produced inhibitory actions on colon cancer cells (HCT-116) and bacterial cells, whereas, no inhibitory action was observed when examined on normal and non-cancerous cells (HEK-293).

Keywords: Anticancer-antibacterial activity; Magnetic properties; Sol-gel route; Sonochemical synthesis; Spinel ferrites.

MeSH terms

Aluminum Oxide
HEK293 Cells
Humans
Magnesium Oxide
Manganese*
Zinc*

Substances

spinell
Magnesium Oxide
Manganese
Zinc
Aluminum Oxide