Genetic analysis of the NR2E1 gene as a candidate gene of schizophrenia

Psychiatry Res. 2020 Nov:293:113386. doi: 10.1016/j.psychres.2020.113386. Epub 2020 Aug 13.

Abstract

NR2E1 is implicated in the regulation of neurogenesis and considered as a candidate gene for schizophrenia. We resequenced all the exons of NR2E1 in 547 patients with schizophrenia and 567 controls from Taiwan. We identified five common SNPs with no association with patients with schizophrenia. Further haplotype-based association analysis showed that two haplotypes within NR2E1 were correlated with the schizophrenia risk. Four rare mutations located at untranslated regions were identified in patients with schizophrenia but not in our control sample. The present study suggests that NR2E1 is likely to play a significant role in conferring susceptibility to schizophrenia.

Keywords: NR2E1; Resequence; Schizophrenia.

Publication types

  • Research Support, Non-U.S. Gov't

MeSH terms

  • Adult
  • Exons / genetics
  • Female
  • Genetic Association Studies / methods*
  • Genetic Predisposition to Disease / epidemiology
  • Genetic Predisposition to Disease / genetics*
  • Haplotypes / genetics
  • Humans
  • Male
  • Middle Aged
  • Mutation / genetics
  • Orphan Nuclear Receptors
  • Polymorphism, Single Nucleotide / genetics
  • Receptors, Cytoplasmic and Nuclear / genetics*
  • Schizophrenia / diagnosis*
  • Schizophrenia / epidemiology
  • Schizophrenia / genetics*
  • Taiwan / epidemiology

Substances

  • NR2E1 protein, human
  • Orphan Nuclear Receptors
  • Receptors, Cytoplasmic and Nuclear