Organic optoelectronic molecules with resonance effects are a striking class of functional materials that have witnessed booming progress in recent years. Various resonances induced by particularly constructed molecular structures can effectively influence key photophysical processes to afford particular optoelectronic properties of the organic resonance materials. The charge transport behaviors were tuned to be dynamic and self-adaptive; emission spectra were made to be very narrow with high color purity; optical bandgaps were significantly reduced, and intersystem crossing was greatly promoted. Therefore, great success has been achieved in various optoelectronic devices by using organic resonance materials to function as smart host materials with high triplet energies, highly luminescent emitters with high quantum yields and narrow emission bands, efficient organic afterglow molecules, and sensitive fluorescent probes. In this Perspective, material design principles, molecular structures and properties, and device performance of organic resonance materials are highlighted and future directions and challenges for this series of amazing materials are discussed.