Bacteria mimics bearing carbohydrates, oligodeoxynucleotides and designed shapes

Jun Hu; Yan Gu; Mengjie Liu; Weidong Zhang; Hong Chen; Gaojian Chen

doi:10.1039/d0cc02239j

Bacteria mimics bearing carbohydrates, oligodeoxynucleotides and designed shapes

Chem Commun (Camb). 2020 Sep 17;56(74):10887-10889. doi: 10.1039/d0cc02239j.

Authors

Jun Hu¹, Yan Gu², Mengjie Liu¹, Weidong Zhang¹, Hong Chen², Gaojian Chen³

Affiliations

¹ Center for Soft Condensed Matter Physics and Interdisciplinary Research and School of Physical Science and Technology, Soochow University, Suzhou 215006, P. R. China. gchen@suda.edu.cn.
² State and Local Joint Engineering Laboratory for Novel Functional Polymeric Materials, College of Chemistry, Chemical Engineering and Materials Science, Soochow University, Suzhou 215123, P. R. China.
³ Center for Soft Condensed Matter Physics and Interdisciplinary Research and School of Physical Science and Technology, Soochow University, Suzhou 215006, P. R. China. gchen@suda.edu.cn and State and Local Joint Engineering Laboratory for Novel Functional Polymeric Materials, College of Chemistry, Chemical Engineering and Materials Science, Soochow University, Suzhou 215123, P. R. China.

PMID: 32804182
DOI: 10.1039/d0cc02239j

Abstract

We utilize a facile and gentle strategy to fabricate bacteria mimics ("bacillus" and "coccus") endowed with carbohydrates, oligodeoxynucleotides and designed shapes via dopamine-polymer based nanoparticle fabrication and DNA-based multivalent interactions. These bacteria mimics with TLR- and CLR-targeted capabilities are demonstrated to exhibit enhanced immune stimulating efficiency.

MeSH terms

Bacteria / chemistry*
Carbohydrates / chemistry*
DNA, Bacterial / chemistry
Dopamine / chemistry
Humans
Molecular Structure
Nanoparticles / chemistry
Oligodeoxyribonucleotides / chemistry*
Polymers / chemistry
U937 Cells

Substances

Carbohydrates
DNA, Bacterial
Oligodeoxyribonucleotides
Polymers
Dopamine