Abstract
In recent years, with the aging of the population and the frequent use of electronic devices, many eye diseases have shown a linear upward trend, such as dry eye disease, glaucoma, cataract, age-related macular degeneration, and diabetic retinopathy. These diseases are often chronic and difficult to cure. Based on the structure and barrier of the human eye, this review describes the pathogenesis and treatments of several intractable eye diseases and summarizes the advanced ocular drug delivery systems to provide new treatment ideas for these diseases. Finally, we also look forward to the prospect of RNAi therapy in the treatment of eye diseases.
Keywords:
drug delivery systems; intractable ocular diseases; ocular barriers; siRNA.
MeSH terms
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Adrenergic beta-Antagonists / administration & dosage
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Adrenergic beta-Antagonists / metabolism
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Antihypertensive Agents / administration & dosage
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Antihypertensive Agents / metabolism
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Cataract / diagnosis
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Cataract / drug therapy
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Cataract / metabolism
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Diabetic Retinopathy / diagnosis
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Diabetic Retinopathy / drug therapy
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Diabetic Retinopathy / metabolism
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Drug Delivery Systems / methods*
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Dry Eye Syndromes / diagnosis
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Dry Eye Syndromes / drug therapy
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Dry Eye Syndromes / metabolism
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Eye Diseases / diagnosis
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Eye Diseases / drug therapy*
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Eye Diseases / metabolism*
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Glaucoma / diagnosis
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Glaucoma / drug therapy
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Glaucoma / metabolism
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Humans
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Latanoprost / administration & dosage
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Latanoprost / metabolism
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Macular Degeneration / drug therapy
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Macular Degeneration / epidemiology
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Macular Degeneration / physiopathology
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Photosensitizing Agents / administration & dosage
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Photosensitizing Agents / metabolism
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Timolol / administration & dosage
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Timolol / metabolism
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Treatment Outcome
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Verteporfin / administration & dosage
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Verteporfin / metabolism
Substances
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Adrenergic beta-Antagonists
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Antihypertensive Agents
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Photosensitizing Agents
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Verteporfin
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Latanoprost
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Timolol