Association between IL6 gene polymorphism and the risk of chronic obstructive pulmonary disease in the north Indian population

Nikhil Kirtipal; Hitender Thakur; Ranbir Chander Sobti; Ashok Kumar Janmeja

doi:10.22099/mbrc.2019.34594.1431

Association between IL6 gene polymorphism and the risk of chronic obstructive pulmonary disease in the north Indian population

Mol Biol Res Commun. 2020 Jun;9(2):41-43. doi: 10.22099/mbrc.2019.34594.1431.

Authors

Nikhil Kirtipal¹, Hitender Thakur^{1

2}, Ranbir Chander Sobti¹, Ashok Kumar Janmeja³

Affiliations

¹ Department of Biotechnology, Panjab University, Chandigarh-160014, India.
² Assistant Professor, Dept. of Biotechnology, SUSCET, Tangori, Punjab-140306, India.
³ Respiratory Medicine, MMCH, Solan, Himachal Pradesh, India.

Abstract

Interleukin-6 (IL6) is encoded by the IL6 gene in human and acts as pro-inflammatory cytokine and an anti-inflammatory cytokine. Recent studies established that IL6 substantially contribute in the diagnosed of systemic inﬂammation for the patients suffering from lung diseases such as chronic obstructive pulmonary disease (COPD). Thereof, this work aimed to investigate the protagonist of IL6 (-174 G/C) genotypes as an essential risk factor for COPD in north Indian population. In the study, a total of 200 clinically diagnosed patients with COPD were selected against 200 patients. Statistical analysis reveleaed that there was no significant association between the IL6 -174 G/C genetic polymorphism and the risk of COPD (P>0.05).

Keywords: Chronic obstructive pulmonary disease; Cytokine; Genotypes; Interleukin-6.