Indirect cell death and the LQ model in SBRT and SRS

Chang W Song; Stephanie Terezakis; Bahman Emami; Robert J Griffin; Paul W Sperduto; Mi-Sook Kim; L Chinsoo Cho

Indirect cell death and the LQ model in SBRT and SRS

J Radiosurg SBRT. 2020;7(1):1-4.

Authors

Chang W Song¹, Stephanie Terezakis¹, Bahman Emami², Robert J Griffin³, Paul W Sperduto⁴, Mi-Sook Kim⁵, L Chinsoo Cho¹

Affiliations

¹ Department of Radiation Oncology, University of Minnesota Medical School, Minneapolis, MN, USA.
² Department of Radiation Oncology, Loyola University Medical Center Chicago, IL, USA.
³ Department of Radiation Oncology, University of Arkansas for Medical Sciences, Little Rock, AR, USA.
⁴ Minneapolis Radiation Oncology and Gamma Knife Center, University of Minnesota, Minneapolis, MN, USA.
⁵ Department of Radiation Oncology, Korea Institute of Radiological & Medical Sciences, Seoul Korea.

PMID: 32802572
PMCID: PMC7406346

Abstract

High-dose hypofractionated SBRT and SRS indirectly kills substantial fractions of tumor cells via causing vascular damage. The LQ formula may work well for certain clinical cases of SBRT and SRS when the indirect/additional tumor cell death secondary to vascular damage is small. However, when the indirect cell death is extensive, the LQ model will underestimate the clinical outcome of SBRT and SRS.

Keywords: LQ model; SBRT; SRS; indirect cell death; secondary cell death.

Publication types

Review