A new standardized data collection system for brain stereotactic external radiotherapy: the PRE.M.I.S.E project

Silvia Chiesa; Barbara Tolu; Silvia Longo; Barbara Nardiello; Nikola Dino Capocchiano; Federica Rea; Luca Capone; Gerardina Stimato; Roberto Gatta; Alessandro Pacchiarotti; Mariangela Massaccesi; Giuseppe Minniti; Francesco Cellini; Andrea Damiani; Mario Balducci; Piercarlo Gentile; Vincenzo Valentini; Federico Bianciardi

doi:10.2144/fsoa-2020-0015

A new standardized data collection system for brain stereotactic external radiotherapy: the PRE.M.I.S.E project

Future Sci OA. 2020 May 27;6(7):FSO596. doi: 10.2144/fsoa-2020-0015.

Authors

Silvia Chiesa¹, Barbara Tolu², Silvia Longo³, Barbara Nardiello², Nikola Dino Capocchiano³, Federica Rea², Luca Capone², Gerardina Stimato⁴, Roberto Gatta⁵, Alessandro Pacchiarotti¹, Mariangela Massaccesi¹, Giuseppe Minniti², Francesco Cellini¹, Andrea Damiani³, Mario Balducci^{1

3}, Piercarlo Gentile², Vincenzo Valentini^{1

3}, Federico Bianciardi²

Affiliations

¹ UOC di Radioterapia Oncologica, Dipartimento Diagnostica per Immagini, Radioterapia Oncologica ed Ematologia, Fondazione Policlinico Universitario A Gemelli IRCCS, Roma, Italia.
² Radiation Oncology Unit, University of Pittsburgh Medical Center, Hillman Cancer Center, San Pietro Hospital FBF, Rome, Italy.
³ Università Cattolica del Sacro Cuore, Istituto di Radiologia, Roma, Italia.
⁴ UOC di Fisica Sanitaria, Dipartimento Diagnostica per Immagini, Radioterapia Oncologica ed Ematologia, Fondazione Policlinico Universitario A Gemelli IRCCS, Roma, Italia.
⁵ KBO.COM Srl, UCSC spinoff, Roma, Italia.

Abstract

Background: In recent years, novel radiation therapy techniques have moved clinical practice toward tailored medicine. An essential role is played by the decision support system, which requires a standardization of data collection. The Aim of the Prediction Models In Stereotactic External radiotherapy (PRE.M.I.S.E.) project is the implementation of systems that analyze heterogeneous datasets. This article presents the project design, focusing on brain stereotactic radiotherapy (SRT).

Materials & methods: First, raw ontology was defined by exploiting semiformal languages (block and entity relationship diagrams) and the natural language; then, it was transposed in a Case Report Form, creating a storage system.

Results: More than 130 brain SRT's variables were selected. The dedicated software Beyond Ontology Awareness (BOA-Web) was set and data collection is ongoing.

Conclusion: The PRE.M.I.S.E. project provides standardized data collection for a specific radiation therapy technique, such as SRT. Future aims are: including other centers and validating an extracranial SRT ontology.

Keywords: big data; brain; personalized medicine; predictive model; stereotactic.