Investigation of Copaifera genus as a new source of antimycobaterial agents

Jéssica Aparecida Alves; Fariza Abrão; Thaís da Silva Moraes; Jaqueline Lopes Damasceno; Marcos Fernando Dos Santos Moraes; Rodrigo Cassio Sola Veneziani; Sérgio Ricardo Ambrósio; Jairo Kenupp Bastos; Mayker Lázaro Dantas Miranda; Carlos Henrique Gomes Martins

doi:10.2144/fsoa-2020-0018

Investigation of Copaifera genus as a new source of antimycobaterial agents

Future Sci OA. 2020 May 29;6(7):FSO587. doi: 10.2144/fsoa-2020-0018.

Affiliations

¹ Research Laboratory of Applied Microbiology, University of Franca, Franca, SP, Brazil.
² Nucleus of Research in Sciences & Technology, University de Franca, Franca, SP, Brazil.
³ School of Pharmaceutical Sciences of Ribeirão Preto, University of São Paulo, Ribeirão Preto, SP, Brazil.
⁴ Federal Institute of Education, Science & Technology of the Triângulo Mineiro, Uberlândia, MG, Brazil.
⁵ Laboratory of Research on Antimicrobial Trials (LaPEA), Institute of Biomedical Sciences - ICBIM, Federal University of Uberlândia, Uberlândia, MG, Brazil.

Abstract

Aim: This paper reports on the antimycobacterial activity of the oleoresins and extracts obtained from Copaifera spp.

Materials & methods: The minimum inhibitory concentration (MIC) and fractional inhibitory concentration index techniques helped to evaluate the effect of these oleoresins and extracts against six strains of mycobacteria that cause tuberculosis.

Results & conclusion: Among the assayed oleoresins and plant extracts, the Copaifera langsdorffii, Copaifera duckei, Copaifera reticulata and Copaifera trapezifolia oleoresins provided the lowest MIC values against some of the tested strains. The combination of Copaifera spp. samples with isoniazid did not evidence any synergistic action. Some Copaifera spp. oleoresins may represent a future source for the discovery of new antimycobacterial drugs due to their low MIC values.

Keywords: Copaifera spp.; Mycobacterium tuberculosis; antimicrobial activity; crude extracts; oleoresins.