In this part of world, nephrology data lack as there is no renal registry, and nephrology is still in its primitive stage. Multan Institute of kidney diseases started tertiary care renal services. We carried out an analysis of our renal biopsies performed here from August 2017 to May 2019. This was carried out to see the spectrum of renal diseases in this area. This is a retrospective analysis of renal biopsies performed at the Multan Institute of Kidney Diseases from August 2017 to May 2019. Renal biopsy was performed using real-time ultrasound. One hundred and seventy-five native renal biopsies were performed during this study period. One hundred and three male (59%) and 72 female (41%) patients underwent renal biopsy. The average age was 36 years, with a range of 16-70 years. Results from our study showed membranous glomerulo- nephritis (36%) as a leading cause of primary glomerular disease in this region. Lupus nephritis (30.3%) was a leading cause in secondary glomerular disease. Reviewing our study and published literature it's pellucid that lupus nephritis is a leading cause of secondary glomerulonephritis worldwide. In terms of primary glomerular disease, spectrum is different globally. This study sets alight to explore membranous nephropathy, which is the leading primary glomerular disease in our studied population.