A Gut Feeling about C9ORF72

Trends Immunol. 2020 Sep;41(9):755-757. doi: 10.1016/j.it.2020.07.012. Epub 2020 Aug 13.

Abstract

C9ORF72 mutations are the most common genetic cause of ALS and FTD, leading to neurodegeneration via complex mechanisms. Mutations also lead to loss of C9ORF72 function and inflammatory diseases in patients and knockout mice. Burberry et al. now show that C9orf72-associated inflammation and premature death in mice are directly modified by the gut microbiome.

Publication types

  • Research Support, N.I.H., Extramural
  • Research Support, Non-U.S. Gov't
  • Comment

MeSH terms

  • Amyotrophic Lateral Sclerosis* / genetics
  • Animals
  • Bacteria
  • C9orf72 Protein
  • Frontotemporal Dementia*
  • Humans
  • Inflammation
  • Mice

Substances

  • C9orf72 Protein
  • C9orf72 protein, human