RIFINing Plasmodium-NK Cell Interaction

Didier Ménard; Sandrine Houzé; Nicolas Papon

doi:10.1016/j.pt.2020.07.017

RIFINing Plasmodium-NK Cell Interaction

Trends Parasitol. 2020 Oct;36(10):802-804. doi: 10.1016/j.pt.2020.07.017. Epub 2020 Aug 12.

Authors

Didier Ménard¹, Sandrine Houzé², Nicolas Papon³

Affiliations

¹ Unité Génétique du Paludisme et Résistance, Département de Parasites et Insectes Vecteurs, Institut Pasteur, Paris, France. Electronic address: didier.menard@pasteur.fr.
² AP-HP, Hôpital Bichat, Laboratoire de Parasitologie-Mycologie, UMR261 Merit, Université de Paris, Paris, France. Electronic address: sandrine.houze@aphp.frsandrine.houze@aphp.fr.
³ Host-Pathogen Interaction Study Group (GEIHP, EA 3142), UNIV Angers, UNIV Brest, Angers, France; Federative Structure of Research 'Cellular Interactions and Therapeutic Applications', SFR 4208 ICAT, Univ Angers, Angers, France.

PMID: 32800428
DOI: 10.1016/j.pt.2020.07.017

Abstract

Among many Plasmodium proteins involved in the erythrocytic cycle, some exposed on the erythrocyte surface drive antigenic variability. Recently, Harrison et al. elucidated the structural basis by which RIFINs activate LILRB1 and suppress immune cell function. This breakthrough points to an additional strategy for survival in the human host.

Keywords: antigen variations; immune response inhibition; malaria; natural killers.

Publication types

Comment

MeSH terms

Antigens, CD
Cell Communication
Erythrocytes
Humans
Leukocyte Immunoglobulin-like Receptor B1
Malaria*
Plasmodium falciparum / immunology
Plasmodium*

Substances

Antigens, CD
LILRB1 protein, human
Leukocyte Immunoglobulin-like Receptor B1