Single and multi-functional coating strategies for enhancing the biocompatibility and tissue integration of blood-contacting medical implants

Maryam Badv; Fereshteh Bayat; Jeffrey I Weitz; Tohid F Didar

doi:10.1016/j.biomaterials.2020.120291

Single and multi-functional coating strategies for enhancing the biocompatibility and tissue integration of blood-contacting medical implants

Biomaterials. 2020 Nov:258:120291. doi: 10.1016/j.biomaterials.2020.120291. Epub 2020 Aug 7.

Authors

Maryam Badv¹, Fereshteh Bayat², Jeffrey I Weitz³, Tohid F Didar⁴

Affiliations

¹ School of Biomedical Engineering, McMaster University, Hamilton, Ontario, Canada; Department of Mechanical Engineering, McMaster University, Hamilton, Ontario, Canada.
² School of Biomedical Engineering, McMaster University, Hamilton, Ontario, Canada.
³ School of Biomedical Engineering, McMaster University, Hamilton, Ontario, Canada; Thrombosis & Atherosclerosis Research Institute (TaARI), Hamilton, Ontario, Canada; Department of Medicine, McMaster University, Hamilton, Ontario, Canada; Department of Biochemistry and Biomedical Sciences, McMaster University, Hamilton, Ontario, Canada.
⁴ School of Biomedical Engineering, McMaster University, Hamilton, Ontario, Canada; Department of Mechanical Engineering, McMaster University, Hamilton, Ontario, Canada; Institute for Infectious Disease Research (IIDR), McMaster University, Hamilton, Ontario, Canada. Electronic address: didart@mcmaster.ca.

PMID: 32798745
DOI: 10.1016/j.biomaterials.2020.120291

Abstract

Device-associated clot formation and poor tissue integration are ongoing problems with permanent and temporary implantable medical devices. These complications lead to increased rates of mortality and morbidity and impose a burden on healthcare systems. In this review, we outline the current approaches for developing single and multi-functional surface coating techniques that aim to circumvent the limitations associated with existing blood-contacting medical devices. We focus on surface coatings that possess dual hemocompatibility and biofunctionality features and discuss their advantages and shortcomings to providing a biocompatible and biodynamic interface between the medical implant and blood. Lastly, we outline the newly developed surface modification techniques that use lubricant-infused coatings and discuss their unique potential and limitations in mitigating medical device-associated complications.

Keywords: Antithrombogenic implants; Biocompatible implants; Biofunctional; Blood-contacting implants; Lubricant-infused coatings; Medical implants; Surface coating; Surface modification.

Publication types

Research Support, Non-U.S. Gov't
Review

MeSH terms

Coated Materials, Biocompatible*
Prostheses and Implants*
Surface Properties

Substances

Coated Materials, Biocompatible