Genetic Associations With Plasma Angiotensin Converting Enzyme 2 Concentration: Potential Relevance to COVID-19 Risk

Circulation. 2020 Sep 15;142(11):1117-1119. doi: 10.1161/CIRCULATIONAHA.120.049007. Epub 2020 Jul 7.
No abstract available

Keywords: COVID-19; angiotensin converting enzyme 2; genome-wide association study; severe acute respiratory syndrome.

Publication types

  • Letter
  • Research Support, Non-U.S. Gov't

MeSH terms

  • Aged
  • Aged, 80 and over
  • Alleles
  • Angiotensin-Converting Enzyme 2
  • Betacoronavirus*
  • COVID-19
  • Chromosomes, Human, Pair 12 / genetics*
  • Chromosomes, Human, Pair 21 / genetics*
  • Chromosomes, Human, X / genetics*
  • Coronavirus Infections / blood
  • Coronavirus Infections / enzymology
  • Coronavirus Infections / epidemiology
  • Coronavirus Infections / genetics*
  • Female
  • Gene Expression Regulation, Enzymologic / genetics*
  • Gene Frequency
  • Genetic Predisposition to Disease
  • Genome-Wide Association Study
  • Genotype
  • Hepatocyte Nuclear Factor 1-alpha / genetics
  • Humans
  • INDEL Mutation
  • Linkage Disequilibrium
  • Male
  • Middle Aged
  • Pandemics
  • Peptidyl-Dipeptidase A / biosynthesis
  • Peptidyl-Dipeptidase A / blood*
  • Peptidyl-Dipeptidase A / genetics
  • Pneumonia, Viral / blood
  • Pneumonia, Viral / enzymology
  • Pneumonia, Viral / epidemiology
  • Pneumonia, Viral / genetics*
  • Polymorphism, Single Nucleotide*
  • Receptors, Virus / biosynthesis
  • Receptors, Virus / blood*
  • Receptors, Virus / genetics
  • Risk
  • SARS-CoV-2
  • Sex Characteristics*
  • Sex Distribution
  • Transcriptional Regulator ERG / genetics

Substances

  • ERG protein, human
  • HNF1A protein, human
  • Hepatocyte Nuclear Factor 1-alpha
  • Receptors, Virus
  • Transcriptional Regulator ERG
  • Peptidyl-Dipeptidase A
  • ACE2 protein, human
  • Angiotensin-Converting Enzyme 2