Objective: To explore the biological mechanisms of tibial transverse transport (TTT) for promoting microcirculation and tissue repair.
Methods: The clinical application and animal model study of TTT were reviewed.
Results: The possible biological mechanisms of TTT for promoting microvascular network formation and tissue repair: ① Tibial corticotomy reduces intramedullary pressure and improves microcirculation; ② Tension stress stimulation promotes microvascular regeneration and accelerates the formation of new "transcortical vessels" network; ③ Systemic mobilization of stem cells, mediating local inflammation, etc.
Conclusion: TTT has been clinically proven to be effective for the management of lower limb ischemia and diabetic foot ulcers. The surgical procedure is relatively easy with little adverse effects on bone structures. The TTT has good application prospects despite the biological mechanisms of which still need further exploration.
目的: 探讨胫骨横向骨搬移（tibial transverse transport，TTT）技术促进微循环再生及组织修复的生物学机制。.
方法: 回顾性总结 TTT 技术临床应用及动物模型的研究。.
结果: TTT 技术促进微血管网重建可能的生物学机制：① 胫骨开窗降低髓内压力，改善微循环；② 张应力刺激促进毛细血管再生，加速新生“跨皮质血管”网的形成；③ 全身干细胞的调动，调解局部炎症反应等。.
结论: 临床研究已证实 TTT 技术对于下肢缺血和糖尿病足溃疡有明显疗效，手术创面较小、易于操作，且不会对骨骼形态造成不良影响，具有较好的应用前景。但 TTT 技术的生物学机制仍需进一步研究明确。.
Keywords: Tibial transverse transport; biological mechanism; microcirculation; tissue repair.